"It is said that Huanyu has completed the development of active compounds and is currently conducting pharmacological evaluation."


    Lang Yongfeng, executive director of Tianfeng Zhengda, said, looking at the paper data on the table.


    As a pharmaceutical company founded on generic drugs, Tianfeng Zhengda has invested a lot of money in new drug research in recent two years.


    However, new drug development can not be achieved in a short period of time, nor is it certain that results will be achieved.


    Even when it comes to the stage of clinical trials, as drug evaluation becomes more and more difficult, there are fewer and fewer new drugs that can pass all three phases of clinical evaluation and go on the market.


    Part of the reason is that it''s increasingly difficult to develop new drugs that are better than the comprehensive evaluation of existing drugs on the market. For example, the FDA approved only 35 new drugs last year.


    For example, Tianfeng Zhengda invested a large amount of money to develop a class II new drug, which has entered the second phase of clinical trial. The result is premature, and all the 75 million US dollars invested in the early stage have been wasted, which is very miserable.


    Of course, drug R & D is also an industry with high investment, high risk and high return.


    Once the drug is successfully launched, the return is amazing.


    There is a word in the industry called "blockbuster", which refers to the annual sales of more than $1 billion of drugs.


    An extreme example is Pfizer''s patented lipid lowering drug Lipitor, which sold an astonishing $10.133 billion worldwide in 2010.


    Hearing Lang Yongfeng''s words, a Four Eyed middle-aged man pushed the mirror frame on the bridge of his nose and said, "this company''s R & D capability is very strong. It''s almost a certainty that it has entered the clinical trial stage. I just don''t know how much success rate it can have?"


    Another man with three whiskers, smoking a cigarette, said, "I think you are all worried about nothing. It''s not even the beginning of clinical trials. There''s nothing to worry about."


    Lang Yongfeng shook his head and said, "you''re wrong. I''m not worried. He Junfeng, the chief scientist of the Chinese Academy of Sciences, has joined their team. Do you know what it means?


    You may not know he Junfeng. He is very proud. At the beginning, Mr. Xie wanted to invite him to serve as the chief expert consultant of our company. He even offered a salary of 10 million years plus bonus stock rights. As a result, he refused without looking at it.


    The fact that he can join universal creatures only means that there must be something he can''t refuse. "


    The middle-aged man with four eyes said, "the general manager means Has Huanyu biology made a breakthrough in the treatment of hepatitis B? "


    Lang Yongfeng definitely nodded: "yes!"


    ……


    Ruiyang pharmaceutical factory, Science Park Avenue, kapok city, Sichuan Province.


    Ruiyang is just a small pharmaceutical factory, mainly engaged in pharmaceutical agent processing factory, with only 30 employees and 4 technicians.


    These technicians, in addition to the daily production of the factory, will also carry out some drug research.


    Mainly painkillers.


    And the reason why they study painkillers is mainly because of Fu Le, the boss and technical director.


    Fu Le used to be an anesthesiologist. Seven years ago, he left his job because of some things. He entered the pharmaceutical industry by chance. After working, he started to study painkillers out of his personal interests.


    However, today, Ruiyang pharmaceutical factory is about to close down, because of the continuous shrinking of the OEM business, the factory has been unable to continue to support, and has to close down.


    At this time, the four technicians in the laboratory, looking at the packed experimental equipment on the ground, were all reluctant to give up their faces. However, it was no use not to give up any more. They always had to live and had to find a new life.


    It is a pity that the boss Fu Le, he is a man with ideals and sentiments, and has paid practical actions for his dream.


    "Let''s go and say goodbye to Lao Fu."


    "Go..."


    Several people looked at the experimental instruments on the ground and left the laboratory with a sigh.


    In the office, a thin faced man in his forties is calculating the company''s property according to the accounting documents.


    After some accounting, after all the expenses have been eliminated, after selling all the equipment, we have not only no money left, but also about 100000 yuan.


    Naturally, this man is Fu Le, the boss of Ruiyang pharmaceutical factory.


    Fu Le gave a bitter smile. In May 2013, it has been seven years since then. In the end, he still has nothing to do.


    Fortunately, his wife had already divorced him and took the child with him. Otherwise, he would not even have a place to stand with him.


    "Very good!"


    Fu Le picked up his mobile phone and called the second-hand equipment recycler, "Hello, boss Zhang, come and pull the equipment..."


    After the phone call, Fu Le closed the computer and planned to leave, but just then, the phone rang on the desk.


    "Hello, who can I ask?"


    At the other end of the phone came an infectious baritone, "are you Mr. Fu?"


    Fu Le: Yes, I am. Who are youBaritone: "I''m Tong Miao, evaluator of the universal biological research foundation. After receiving your application, we have evaluated your company and the experimental project. Now we have some questions to ask you. Is it convenient for you now?"


    "World Foundation?" After listening to the other party''s words, Fu Le Leng for a moment, and then suddenly remembered that he seemed to have filled in an application form last month.


    "By the way, the worldwide research grant."


    Fu Le remembered for a moment.


    Last month, he applied for one million research grants from the universal research foundation.


    Although I know that the hope is not very good, but at that time is also hopeless, holding the hope in case to fill in some information.


    I didn''t expect that the foundation would call itself.


    "Well, you." Fu Le unconsciously, even the words have become respectful up.


    No way, who let the other side is the God of wealth, Ruiyang can continue to maintain, depends on the other side loose mouth.


    Tong Miao: "the whole telephone recording."


    Fu Le: "Well! I see. "


    Tong Miao: "well, it''s time to start. I think it is mentioned in the application instructions that you have been an anesthesiologist for 11 years. Why didn''t you do it in the end? "


    Fu Le: "because of emotional problems."


    Tong Miao: "then why do you want to study painkillers?"


    Fu Le: "because I believe that any real anesthesiologist would like to develop an analgesic that can effectively block pain without producing euphoria."


    Tong Miao: "I don''t quite understand. Can you tell me the reason in detail?"


    Fu Le: "good! It sounds like a bit of a nonsense. Painkillers are a part of the job. Isn''t it better to provide additional pleasure and comfort?


    However, countless problems in the world lie in the feeling of "make you happy".


    The word euphoria sounds magnificent, but it is almost two in one with "d", "d addiction" and "withdrawal reaction".


    You may not know that a sad fact is that saving hundreds of millions of patients with cancer and severe pain, as well as the necessary analgesics for surgery, is being abused by drug addicts who pursue pleasure and become the "d" product.


    For example, the most commonly used analgesics in front of the window is opioid drugs. The name of opioid here is actually euphemistic English translation, in fact, the exact name is y tablet.


    Opioid drugs originally refer to the resin exudate extracted from the capsule of Papaver poppy. With the development of chemical industry, opioids have been transformed into semi synthetic and total synthetic narcotic and analgesic drugs.


    Morphine, buprenorphine, fentanyl, dolantin, tramadol and methadone are commonly used in clinic. There are also various kinds of analgesic paste and emulsion. Many of them also contain opioids.


    Opioids, as strong analgesics, enter the nervous system and combine with opioid receptors, which can quickly improve the pain threshold of the body, reduce the body''s feeling of pain, and produce strong analgesic effect.


    But its other role is to make users have a special sense of joy and very happy, comfortable feeling, which is the root cause of the abuse of such drugs.


    Euphoria and addiction can hardly be separated. Extraordinary pleasure is pleasure and hell.


    Shuang is not a problem. The problem is to be cool all the time.


    There is almost no end to the desire of human beings to seek strong stimulation subjectively.


    After experiencing a far more than imagined pleasure, any ordinary stimulus is like tickling. Once the threshold of pleasure is raised, it is difficult to be pressed down.


    The so-called from extravagance into thrifty is difficult, cool also want to cool, is addiction.


    One addictive word has destroyed countless people.


    As an anesthesiologist, I am very sad to see that many drugs originally invented for the benefit of mankind have been abused into product D, which not only stigmatizes the drug, but also commits serious crimes against patients with extreme pain and legitimate analgesic needs.


    , for example, chloramine, Kwai Tong, is an excellent short acting analgesic in pediatric anesthesia. It has the advantages of quick onset, fast metabolism, and the function of separated anesthesia. It is very suitable for pediatric fast track surgery.


    But now it''s called k-powder, and no one knows it used to be a good helper for anesthesiologists.


    Because of this, I especially hope to understand the whole pain signal as soon as possible, and develop an analgesic that can effectively block pain without relying on opioid receptors... "


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