Before the completion of his own laboratory, Du Xingyu temporarily joined Xie Ziqian''s team to study stem cell cultivation and induction technology.


    In short, stem cells are a kind of cells with unlimited or eternal self-renewal ability, which can produce at least one type of highly differentiated progeny cells. It is mainly divided into totipotent stem cells, pluripotent stem cells and single stem cells.


    Totipotent stem cells have the potential to differentiate into complete individuals. For example, Du Xingyu cloned Tyrannosaurus Rex before, which is to artificially induce totipotent stem cells after compiling the genetic information of Tyrannosaurus Rex, and then cultivate them into embryos.


    Pluripotent stem cells have the ability to produce a variety of cells, but they cannot develop into individuals.


    Single stem cells can produce only one type of cells.


    This time, their research direction is mainly pluripotent stem cells and single stem cells.


    Xie Ziqian''s team''s research project is to use stem cell cultivation and induction technology to cultivate human epithelial cell layer.


    The goal put forward by Du Xingyu is to directly cultivate human large organs in vitro. I don''t know how much the difference is.


    "Establish an in vitro organ cultivation project." Du Xingyu simulated the new project on the science and technology simulator.


    It is also a very complex thing to cultivate human organs alone without "cloning" human beings.


    What Du Xingyu did first was to input the database of Peking University and the research data of the hospital into the technology simulator to obtain the necessary information.


    Technology simulator: "research progress, 30 percent."


    "Every organ needs different cultivation methods." Du Xingyu narrowed his goal and decided to start with a human organ.


    "According to the data, the kidney is the most transplanted organ and the most needed organ in mankind." Du Xingyu thought a little and decided: "let''s start with cultivating the kidney in vitro!"


    Du Xingyu began to build a human kidney model on the science and technology simulator.


    He needs to trace the source, find stem cells that can develop into kidneys, study all the conditions needed for kidney development, and start from scratch step by step.


    ……


    "You say, cultivating kidney in vitro? I admit that Du Xingyu is really insightful in stem cell cultivation technology. But isn''t this a problem?" during the period of cooperation with Du Xingyu, the cell experts and medical experts in the team still have some doubts.


    "Yes, originally we were going to study and cultivate epithelial cells, but now the difficulty has increased so much that we can''t see the end!" a team member shook his head and said, "Hey, it''s a headache. I don''t know what the director thinks. Let''s listen to him."


    "Who knows... Originally, our project was a plan to carry out in vitro organ cultivation research with island countries, South Korea and the Netherlands. Now island countries, South Korea, the Netherlands and France have made good progress. We can''t make progress now. When we wait for the exchange meeting, it will be a great shame." a cell expert worried.


    Their project is part of the "cell biology research program" jointly carried out by five top medical research institutions in five countries. At that time, all parties will conduct academic exchanges. If they fail to achieve any results, they will lose face and go abroad.


    "I think this young man is praised for cloning Tyrannosaurus Rex. It''s a little too floating!" an old expert said. "When he falls several times, he will understand that scientific research doesn''t depend on his mouth!"


    ……


    "The eighth cultivation failed." two months later, Du Xingyu had simulated the process of organ cultivation in vitro, but the human physiological mechanism was too complex, and many simulations failed.


    "I have completed the induction of stem cells. The most difficult thing is how to ensure the normal development and survival of organs in vitro." this gives Du Xingyu a headache.


    "Maybe I should redesign a human simulation system to simulate the role and physiological response of each organ and even each cell in the human body, and then simulate an ''in vitro kidney culture dish'' according to these."


    "It is recommended to turn on the biological observation function," the science and technology simulator warned. "If you use 10 million energy points to turn on the biological observation function, you can get more detailed information, which is more detailed than the biological instrument observation of human beings in the world."


    "Still have this function?" Du Xingyu surprised, "how to use it?"


    Du Xingyu already has 10 million energy points. The popularity of cloning Tyrannosaurus Rex last time made him accumulate a lot of energy points.


    After consuming 10 million energy points, the new function is turned on.


    The science and technology simulator warned: "the biological observation function is to open the four-dimensional perspective to observe three-dimensional organisms, and you can get the most comprehensive information. I can record this information, but your brain can''t accept so much information, so you can only watch it for three seconds."


    "Let''s start!" Du Xingyu was also very curious, looking at organisms from a four-dimensional perspective, what is the experience,


    "Target selection, your own body, open high-dimensional perspective observation!" said the technology simulator, and Du Xingyu saw a new self.


    If a normal human looks at him in the three-dimensional world, he sees one side of a three-dimensional image. The perspective is a three-dimensional picture from the inside.


    From the four-dimensional perspective, Du Xingyu''s line of sight can actually "pass through" his own body!


    He can see every "three-dimensional surface" of his body, just like starting an all-round perspective! The visual angle can see inside the body from outside the body, or outside the body from inside the body.


    His every organ, every blood vessel and cell are exposed to the four-dimensional perspective without any disguise.


    For example, his body also has countless pairs of eyes to watch himself at the same time. A large amount of information poured into his brain in an instant. Du Xingyu felt his brain was swollen. He couldn''t bear this much information.


    Fortunately, even if the technology simulator cuts off the four-dimensional perspective, otherwise he will be in a coma.


    "Biological information has been recorded," said the technology simulator. "It is now possible to specify the external conditions required for the development and growth of human kidneys."


    "Hoo!" Du Xingyu hasn''t recovered from the picture just now. From a high-dimensional perspective, there are almost no secrets for all three-dimensional objects and creatures!


    After a while, he said, "go on!"


    ……


    After knowing the conditions required for human kidney development, it is much easier to design an in vitro kidney culture dish.


    Du Xingyu conducted several simulations and finally got a successful result.


    Now you can start experimenting in the real world.


    ……


    "Based on my research in recent months, I have roughly understood the technical points of organ cultivation in vitro." Du Xingyu said at the meeting of the research team: "I think it''s time to start the experiment."


    "Have you understood?" Xie Ziqian was surprised. Du Xingyu had been collecting all kinds of information during this period. It seems that I''m not here to study, but to learn.


    "Yes." Du Xingyu nodded.


    The team members were calm on the surface, but they didn''t think so.


    "We can start the mouse breeding experiment first," Du Xingyu continued


    He wanted to cultivate human organs directly, but before the mouse test was successful, it was obvious that the hospital would not allow to start the human organ test directly.


    "Of course." Xie Ziqian didn''t refuse. He did the mouse test as he liked.


    Up to now, Xie Ziqian believes that the role of letting Du Xingyu join the team has been achieved. The stem cell culture technology proposed by Du Xingyu has made great progress in the cultivation of epithelial cells.


    As for in vitro kidney cultivation, Du Xingyu likes to toss about. Anyway, there are many experimental mice.


    Du Xingyu began to take action, because he had carried out it once on the science and technology simulator, and his progress was very smooth.


    An adult mouse can develop and mature in more than 30 days. Du Xingyu selected a group of mice and made an in vitro cultivation device for mouse kidney. Then extract their stem cells for induction.


    Next, the development of mouse kidney in vitro was observed every day.


    In the first few days, the members of the research team regarded it as a novelty. No one really thought Du Xingyu''s experiment would succeed.


    However, only a few days later, their attitude changed 180 degrees.


    In the mouse kidney in vitro cultivation device, the mouse stem cells actually began to differentiate into the kidney!


    The person who first discovered it was a cytologist named Di Jingwu.


    He was also one of the people who initially thought that Du Xingyu''s in vitro kidney cultivation could not succeed. Di Jingwu privately told his colleagues, "in vitro kidney cultivation is unlikely to succeed within 30 years or even 50 years!"


    "How can a human kidney grow normally in vitro? Unless he clones a person! Now the law does not allow it!"


    After all, di Jingwu is curious about the mouse kidney cultivation device designed by Du Xingyu. He always wants to know how it can replace the mouse body structure and let the kidney develop and exercise its function intact.


    So when he had time, di Jingwu went to "pay attention" to this institution to observe the cell development inside.


    On that day, di Jingwu went to observe the cell growth as usual. He was surprised to find that the original mouse stem cells had begun to differentiate into kidney related cells!


    "Actually really differentiated?" Di Jingwu was surprised. "It''s not a single cell tissue, but the rudiments of various cells in the kidney. They all appeared!"


    "Can he really do it?"


    Di Jingwu felt incredible. He immediately called Xie Ziqian and said, "director, something big has happened!"


    "Ah?" said Di Jingwu. Xie Ziqian was startled. "Something happened in the hospital?"


    "No, it''s the laboratory!" Di Jingwu said quickly. "I just went to observe the cultivation device of Du Xingyu. Guess what I saw?"


    "What do you see? Lao Di, how do you like to hang people''s appetite now?" Xie Ziqian said speechless.


    "I observed that the mouse stem cells induced by him have begun to differentiate into liver organs! Moreover, these cells are full of activity and look like they can continue to develop!" said Di Jingwu.


    "What? Really divided?" Xie Ziqian was surprised. "Wait, I''ll come right away!"