Xie Ziqian had several meetings to hold. Hearing Di Jingwu''s words, he immediately rushed to the laboratory.
"Where? Let me see!" Xie Ziqian said.
"This is the image under the electron microscope!" Di Jingwu opened the computer page and showed it to him.
"There is also the image comparison of the previous few days. At the beginning, these are just a group of mouse stem cells. After several days of division and differentiation, they have begun to develop in the direction of kidney organs!" said Di Jingwu.
"My God, he really did it?" Xie Ziqian had never been so surprised. No one, including him, would think Du Xingyu''s experiment could succeed.
If his in vitro organ cultivation is successful, it will definitely be a technological invention that will change the world! What Nobel Prize in medicine, geldana prize in medicine or something, I''m afraid I''ll get a soft hand!
This is a technological discovery that can benefit all mankind. Now it has been revealed!
"How did he do it? How did he induce and differentiate successfully in vitro? Why could these kidney cells survive in vitro? How was his culture device designed?" Xie Ziqian asked.
"Er..." Di Jingwu was a little embarrassed and said, "I don''t understand. Everyone is busy cultivating epithelial cells, and they don''t pay much attention. Most of them are completed by him alone."
He didn''t say anything, because people in the research group thought Du Xingyu was a waste of time, so they were not interested and spent their energy on their original research objectives.
"No, I have to find it!" Xie Ziqian has realized the importance of this matter, which is a bioscience discovery that can change the world!
He immediately called Du Xingyu and said excitedly, "Xiao Du, in your Petri dish, the directional differentiation of stem cells has been successful! Just now we have observed that stem cells begin to differentiate into kidneys!"
"Almost." Du Xingyu replied with an "as expected" tone, "today should begin to divide."
"You must not be excited?" Xie Ziqian wondered. "This step has shocked the bioscience and medical circles!"
"It''s OK," said Du Xingyu. "The experiment has just begun. It''s still unknown whether the kidney can mature in vitro and whether the transplantation will succeed. Besides, even if it is successful, it''s only a mouse experiment, and it hasn''t reached the stage of human experiment."
Xie Ziqian sighed: "it''s strange that you can have this calm and calm at your age."
"Anyway, this is a good start!"
"Next, we will try our best to study this project!"
Xie Ziqian immediately informed all members of the team that after learning that Du Xingyu had directed mouse stem cells to differentiate into kidney cells, all members had refreshed their world outlook.
"Can he really do it? It''s a genius!"
"I thought it was a joke at first. I can do it..."
"Today''s young people are amazing!"
"How long is his brain? Why is he so much smarter than us?"
Now, no one dares to underestimate Du Xingyu''s words, because they know. Du Xingyu''s research findings on inducing mouse stem cells to differentiate into kidney tissue exceeded their lifelong research results!
The laboratory did not immediately release the news because they were still waiting to know whether these mouse kidneys could be used for organ transplantation.
After more than 30 days of culture, ten mouse kidneys have been cultivated in the mouse kidney cultivation device, which come from different mouse stem cells.
The owners of these stem cells have grown into mature mice that can be used in experiments.
"Today, we are going to carry out organ transplantation in mice!" Xie Ziqian and others looked serious in the laboratory.
They are all old experts, not to mention the mouse test. They don''t know how many times they have experienced surgery, but this time they are particularly nervous.
Because the organ transplanted this time is cultivated by Du Xingyu in vitro! Meaning is extraordinary!
After being anesthetized, ten mice lay on the operating table waiting for organ transplantation.
The operation was performed by the most professional surgeon Jing Jian, who paid 120 points of attention.
"It''s done!" after the operation, Mr. Jing sighed. He hasn''t been so nervous for a long time.
"At present, the vital characteristics of mice are stable and there is no abnormal reaction for the time being."
"Continue to observe and see if these cultivated kidneys are really useful!"
These ten white mice have become the "object" of everyone''s attention. Their physical health affects everyone''s heart.
In the first few days, the mice were recovering from the surgical trauma.
After a period of time, the mice basically recovered from the injury and were already alive, and some even had been able to mate.
"The target physiological performance of organ transplantation is very good," Du Xingyu said at the research group meeting. "This is the same as what I thought at the beginning. Because stem cells are taken from themselves, there is no organ rejection. The functions of the transplanted kidney are also normal."
"The first stage of this experiment should be regarded as a success."
Du Xingyu finished, and warm applause broke out in the conference room. Everyone was very happy. Before Du Xingyu joined the research project, they never thought they could do this!
Now, as long as their successful mouse research is announced to the world, biologists and medical scientists all over the world will look at it!
"Beyond expectation!" Xie Ziqian said with a smile, "I really didn''t expect that the mouse test could be so successful. It seems that it''s the wisest choice to invite Xiao Du to join our research group."
"Yes, we should be the first team in the world to successfully cultivate mouse organs in vitro!"
"This discovery is very important. It will accumulate experience for us to cultivate human organs!"
"Don''t worry about academic exchanges later."
Du Xingyu asked, "director, when can we start the human organ cultivation experiment?"
Xie Ziqian has thought about this problem. He said: "generally, I don''t recommend carrying out human organ cultivation test so early. However, our first stage is so smooth, so it''s the wisest choice to start human organ cultivation test as soon as possible."
"We achieved results one day earlier, and millions of patients in the world who need organ transplantation can get the hope of rebirth."
"So I''ll arrange it as soon as possible."
Opening the in vitro cultivation test of human organs still needs some beneficial processes. Thanks to Xie Ziqian''s efforts, they soon obtained approval, and one patient was willing to participate in the medical trial.
"Sun Dahai, male, 45 years old. At the end of chronic renal failure, he has reached the stage of uremia and must undergo kidney transplantation."
"But for more than a year, the country has not found a suitable source of kidney. If kidney transplantation is not carried out as soon as possible, the patient''s life will be difficult to continue."
"His family has signed a voluntary medical research experiment to cultivate his kidney, which is our goal in the next stage." Xie Ziqian announced the goal of the second stage of the experiment.
Du Xingyu has also seen the patient''s data. The patient is an ordinary truck driver and the head of the family. There are old people and small people. He suffers from chronic renal failure and runs out of family wealth.
Nationwide, there are about 150 patients who need kidney replacement, and only one can get the chance of kidney transplantation!
And it''s just an opportunity. Only some of them can transplant successfully. Even if the transplant is successful, you need to keep taking drugs to resist rejection
"The first step in transforming human beings is to start with organ cultivation," Du Xingyu thought.
He began to research according to his achievements in the simulator.
In the first step, Du Xingyu must first obtain sun Dahai''s related stem cells before inducing differentiation.
Fortunately, Du Xingyu has had the experience of obtaining T-Rex stem cells, and this time it will be much smoother.
The second step is to induce stem cells to differentiate into renal organs and culture them in an in vitro device.
In mice, they have completed this process. But this is a human organ. No one dares to say that he will succeed.
……
The development of human organs is much slower than that of mice, but patients can''t wait that long. Therefore, during the cultivation process, the team used hormones to stimulate organ development, which may lead to a lower life span of the kidney than the normally developing kidney.
But the patient is already in his forties. The "life" of the cultured extracorporeal kidney must be longer than that of his current normal kidney!
As time went by, in the human kidney in vitro cultivation device designed by Du Xingyu, a human kidney was connected with various artificial physiological "organs" and developed rapidly.
……
"In a month, our kidneys will probably mature and undergo surgery," Tong Kai, the attending doctor, told sun Dahai''s family in the doctor''s office of the Affiliated Hospital of Peking University.
"Doctor, is there really no problem?" although he has asked many times, sun Dahai''s mother Zhao Fang still asked.
This is related to her son''s life. Even if she asked 10000 times, she felt less.
Looking at the worried and praying eyes of the patient''s family members, Tong Kai comforted: "I can''t guarantee the absolute success of the operation. But I asked the director. The experiment is very good and the possibility of success is very high."
"As family members, you should also stabilize your emotions, so that patients can stabilize their emotions, which is more suitable for surgery."
"Thank you, doctor!" Sun Dahai''s parents can only pray silently in their hearts. This time, a new medical technology will be born.
It''s less than ten days before organ transplantation.
Several foreign teams who had previously carried out the in vitro organ (mainly skin tissue) research program with Xie Ziqian''s team were also invited to the Affiliated Hospital of Peking University for academic exchanges.
Before their arrival, these teams have achieved certain results and have been published. So when these foreign experts came, they were more or less proud.