Office of the Institute of cryptococcosis.


    "Hello, Zhou Suo. I''ve known each other for a long time. Today I finally see the real man."


    "Ha ha, the same thing! I have admired you for a long time, and I have always wanted to visit you, but I have never been able to do so. "


    Zhang Wen held Zhou Wen''s hand and said with a smile: "if I knew you would go to Zhonghai last time, I would not go on a business trip."


    Zhou Wen laughed, "that''s no good. It''s a crime to delay your work."


    Although they were more than 20 years old, they were like old friends at first sight. They were very fond of each other and chatted quite opportunely!


    In addition to the well-known titles of Zhang Wen, such as the director of the Department of infection of Huashan Hospital, the director of the Department of internal medicine, and the doctoral supervisor of the medical school of Fuyang University, Zhang Wen also has an identity as a biomedical researcher of Fuyang University.


    Don''t underestimate the identity of this biomedical researcher. Zhang Wen''s main research direction is microbiology.


    All his achievements can be said to have come from microbiology.


    "OK, Zhou Wen, don''t patronize Zhang Wen. Let me introduce you to you. This is pan Renfeng, director of infection department of harmony hospital."


    "Hello, Mr. Pan..."


    In the laboratory in the morning, when these big guys came over, Zhou Wen didn''t have time to get to know each other.


    Different from the academic junta who are busy with political life in China, today''s academic leaders are really working in the front line.


    Everyone''s personality is very subsequent and approachable.


    After a brief exchange of greetings, everyone''s topic naturally focused on the neutralization effect test.


    There was a heated discussion.


    ……


    ……


    At the Institute of cryptococcosis, Jiangzhou hospital, the news of successful isolation of antigenic B cells has spread widely.


    As soon as the news came out, it immediately attracted the attention of domestic medical circles.


    Before the domestic medical community had reacted, the latest news revealed that it was not only a simple separation, but also a successful amplification and expression of antibodies.


    This is not only concerned about that simple, but also began to inquire about the truth of the matter.


    However, at this time, Jiangzhou hospital announced that the antibacterial cells had passed the neutralization effect test.


    A stone stirs a thousand waves!


    Now everyone can''t sit still.


    Through the neutralization test, in other words, the next step is to start clinical trials. As long as there is no rejection or major side effects, it can be officially launched into the market as a new cryptococcal vaccine.


    That''s great news.


    According to the latest research published in the proceedings of the National Academy of Sciences of the United States, the infection caused by Cryptococcus neoformans causes about 1 million deaths in the world every year, of which about 600000 are in sub Saharan Africa.


    Cryptococcus neoformans mainly enter the human body through the lungs and can be distributed throughout the body, including the brain.


    The result of infection is cryptococcosis, which causes chest pain, dry cough, abdominal distension, headache, blurred vision or mental disorder. This infection can be fatal, especially without antifungal treatment.


    Even with treatment, the mortality rate is as high as 30%.


    It''s terrible!


    Soon, the health organizations of many countries called and even the World Health Organization called for consultation.


    In addition, some large pharmaceutical groups and research institutes have also called to inquire about the technology of isolating antigenic B cells


    The successful replication of antibacterial cells is of great significance.


    ……


    At a time when the global medical community is paying attention to this matter, the medical school of Jiangzhou University and the medical school of Tanzhou university are also discussing with Zhou Wen about the patent ownership of some technologies.


    At the beginning, Jiangzhou medical college did not expect Zhou Wen to successfully replicate antibacterial cells. The main purpose was to increase the influence of Medical School of Jiangzhou university with the help of Zhou Wen''s influence on prion.


    The same is true of Tanzhou medical college. In fact, the purpose is the same. The best way to succeed is to earn an academic reputation if it fails.


    But I never thought that Zhou Wen succeeded.


    There''s no place to reason about this.


    Now that we have succeeded, there is no need to say much about halo and honor, but they are all superficial things.


    But the issue of core interests is also very important.


    That is the issue of patent ownership.


    There are at least 5-10 patented technologies involved in the anti cryptococcosis vaccine, each of which can bring long-term and huge benefits. This must be clarified as soon as possible to avoid unnecessary disputes in the follow-up.


    Although Zhou Wen is not willing to talk about such a naked matter as soon as the results come out, he can''t help it. The leaders of the two universities are in a hurry, so he can only come.


    Department of medicine, Jiangzhou University, conference room.


    Chen Tongguang, director of the medical department, said: "Professor Zhou, you are the main person in charge of the project. Tell me your opinion!"


    Zhou Wen said to the point: "OK, I''ll talk about my opinion.The Institute of cryptococcosis was established with the support of your leaders, and there was an agreement between the two parties before, so I think it is OK to distribute according to the agreement.


    After the follow-up clinical trial and marketing of the vaccine, 90% of the costs and benefits generated will be evenly distributed by Jiangzhou University and Tanzhou University, and the remaining 10% of the revenue (excluding the cost of clinical trials) will be distributed by all our laboratory staff. "


    Lu Yongfeng, director of the medical school of Tanzhou University, asked, "of course we know about this. What about other patents?"


    Zhou Wenqi said strangely, "what patents are there?"


    "Cell separation technology, amplification technology, determination technology, primer design data and so on, all of which should be included," Lu said, smoking


    Zhou Wen looked at Chen Tongguang and asked, "director Chen, is this the result of your discussion?"


    Chen Tongguang said with helpless color: "this is not the meaning of the medical department, it is proposed by the school."


    Zhou Wen nodded and said, "OK! Let me be frank. Except for vaccines, the rest of the patented technologies are all owned by me. I have made it clear when I was the deputy director of the Research Institute at the beginning, and I have written it in black and white in the contract. "


    Lu Yongfeng smoked a cigarette and said slowly: "words can''t be so said! The contract belongs to the contract, but we can''t ignore the fact.


    It is true that the vaccine was developed under the leadership of Professor Zhou, but in the process, other researchers have also paid hard work and sweat. You can''t take advantage of all the benefits alone, but others have nothing? "


    Zhou Wen frowned, "what does it mean that I take all the benefits by myself?


    Without me, does director Lu think antigenic B cells can be isolated?


    Without me, does director Lu think that sequence amplification can be successful?


    Without me, does director Lu think the vaccine can be developed?


    We should not only respect the facts, but also be conscientious, and we should not ignore the facts! "


    Seeing that the atmosphere in the conference room was a little stiff, Liu, Secretary of Tanzhou University, who came to preside over the negotiation, said with a smile: "don''t be angry, Professor Zhou, and listen to me.


    Vaccine research is a good thing. There is still a lot of work to be presided over by Professor Zhou. Let''s have a peaceful talk. "


    After a pause, he said, "do you think this will work? Let''s step back. Professor Zhou will take out the separation technology and amplification technology, and you will own the rest."


    Zhou Wen said with a smile: "secretary Liu, do you think it is possible?"


    After a pause, Zhou Wen said: "at the beginning, director Cheng asked me to mutate the cryptococcal serum, but I gave it without saying a word. Later, you Xiangya Hospital successfully cured the new cryptococcosis, and won numerous honors and applause.


    And I was criticized and my bonus was deducted!


    Later, you Xiangya Hospital wanted to set up a cryptococcosis Research Institute. I was specially invited to be the first person in charge of the project. I was not willing to. It was only after your leaders repeatedly invited me that I agreed.


    It also agreed to give 90% of the profits to both medical schools.


    Now let me step back.


    I''m sorry, secretary Liu. I can''t step back today. "


    Said Zhou Wen stood up, "either according to the contract, or you go to sue me!"


    With that, Zhou Wen turned around and left a room full of people staring at each other.


    ……


    PCR group, detection center of Jiangzhou hospital.


    In the office, Zhang Shuguang, Yang Liqun and Wang Huiyao are chatting.


    Because Zhou Wen left, Zhang Shuguang could not find a successor, so he has been concurrently the leader of PCR team.


    As for Wang Huiyao, he and Yang Liqun are good friends, so I came here to see him today.


    "It''s a pity that the boy left." Zhang Shuguang said, smoking.


    Yang Liqun said with a smile: "I don''t think it''s a pity! If he was still in the PCR group, how could he have grown to this point? "


    Wang Huiyao also smoked and sighed: "yes! His biological talent is the only one I''ve seen for so many years. It''s unprecedented. "


    "I think it''s normal," Yang said! The vast majority of geniuses are made famous by teenagers.


    For example, Newton was only 24 years old when he discovered the three laws, the law of universal gravitation and calculus, Einstein was 28 years old when he discovered relativity, and Xue dinge was only 26 years old when he proposed the theory of glass dynamics. Who else is there? "


    Zhang Shuguang added: "Heisenberg discovered the uncertainty relationship at the age of 26, Bohr proposed the hydrogen atom model at the age of 28, and Josephson predicted the Josephson junction at the age of 24."


    Wang Huiyao nodded and then added: "Anderson seems to have discovered positron at the age of 22. The youngest Nobel laureate is Prague, who seems to be only 21 years old."


    After Wang Huiyao finished, Yang Liqun followed: "and Maxwell discovered the electromagnetic law when he was 24 years old."


    Zhang Shuguang said, "you say, why is this?"


    As soon as his voice dropped, Zhou Wen''s laughter came from the open door of the office, "because when a person receives a lot of cutting-edge knowledge in the shortest time, he is most likely to find out.At this time, the constraints are small and the thinking is quick, and the most critical and useful information can be found from a large number of complicated materials.


    However, if you use a step-by-step approach, you may gain a lot. Each knowledge point is well grounded and logical, but at the same time, it produces thinking inertia, and it is difficult to make breakthrough discovery again!


    As you get older and experience more, you think less.


    Because many times, experience can take the place of thinking. In this way, there will be fewer and fewer problems. Solving problems always depends on experience first. In the end, there will be basically no new problems, and there will be no new discoveries... "


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